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THP-PEG10-t-butyl acetate
- 商品名称： THP-PEG10-t-butyl acetate
- Product No.： BK03234
- Product Name： THP-PEG10-t-butyl acetate
- 中文名称： 四氢吡喃醚-十聚乙二醇-乙酸叔丁酯
- Appearance： 液态
- Formula： C31H60O14
- M.W.： 656.80
相关描述
THP-PEG10-t-butyl acetate is a PEG10 derivative containing a tetrahydrofuran ether (THP) protecting group and a t-butyl acetate terminal group. Its structure consists of a THP cyclic ether moiety connected to the PEG10 chain via an oxygen atom, with the chain terminated by t-butyl acetate. The molecular formula is C₃₀H₅₈O₁₃, and the molecular weight is approximately 626.77. The production process employs an ethylene oxide (EO) ring-opening polymerization method, initiated by KOH under nitrogen protection. Reaction temperature is strictly controlled between 120-125°C to avoid side reactions. The final product is obtained through degassing, neutralization, and purification to achieve high purity. This compound is commonly used in PROTAC molecule synthesis as a flexible linker or as a hydrophilic spacer in drug delivery systems. Its THP protecting group can be removed under acidic conditions, enabling precise release of functional molecules.
所属分类： 乙酸叔丁酯链接剂
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