产品中心
PRODUCTS
产品分类
Methyl-PEG5-acid
- 商品名称： Methyl-PEG5-acid
- Product No.： BK03264
- Product Name： Methyl-PEG5-acid
- 中文名称： 甲基-五聚乙二醇-羧酸
- Appearance： 液态
- CAS.： 1347750-72-4
- Formula： C14H28O8
- M.W.： 324.37
相关描述
Methyl-PEG5-acid (CAS: 1347750-72-4) is a linear polyethylene glycol (PEG) derivative with the molecular formula C₁₄H₂₈O₉ and a molecular weight of approximately 340. Its structure consists of a pentaglyme chain terminated with a methoxy group (MPEG5) and an end carboxylic acid group (-COOH), combining a hydrophilic PEG chain with a reactive carboxylic acid terminal group.
The production process typically involves ring-opening esterification of methoxypolyethylene glycol with maleic anhydride, catalyzed by pyridine. The reaction is carried out at 125°C for 6 hours, followed by ether purification to obtain a high-purity product. The carboxylic acid group can be activated with EDC/NHS to form amide bonds with amines or directly participate in esterification reactions.
This product is widely used in the biomedical field, such as drug carrier modification, antibody-drug conjugate (ADC) linkers, surface functionalization of nanomaterials, and polymer material modification (e.g., enhancing coating adhesion). Its low immunogenicity and high water solubility significantly improve the biocompatibility of materials.
所属分类： 甲基链接剂
在线询价
