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(1R,8S,9S)-BICYCLO[6.1.0]NON-4-YN-9-YLMETHYL SUCCINIMIDYL CARBONATE/BCN-Osu
![(1R,8S,9S)-BICYCLO[6.1.0]NON-4-YN-9-YLMETHYL SUCCINIMIDYL CARBONATE/BCN-Osu](/npublic/img/s.png "(1R,8S,9S)-BICYCLO[6.1.0]NON-4-YN-9-YLMETHYL SUCCINIMIDYL CARBONATE/BCN-Osu")
- 商品名称： (1R,8S,9S)-BICYCLO[6.1.0]NON-4-YN-9-YLMETHYL SUCCINIMIDYL CARBONATE/BCN-Osu
- Product No.： BK03213
- Product Name： (1R,8S,9S)-BICYCLO[6.1.0]NON-4-YN-9-YLMETHYL SUCCINIMIDYL CARBONATE/BCN-Osu
- 中文名称： BCN-Osu
- CAS.： 1426827-79-3
- Formula： C15H17NO5
- M.W.： 291.30
相关描述
BCN-Osu (CAS No. 1426827-79-3) is a bifunctional bioorthogonal reagent whose molecular structure consists of bicyclo[6.1.0]nonyne (BCN) covalently linked to N-hydroxysuccinimide ester (Osu) via a short linker. The production process starts with BCN-COOH as the raw material, which undergoes activation of the carboxyl group by EDC/NHS to form the Osu ester. The reaction proceeds at room temperature for 10-14 hours, monitored by thin-layer chromatography (TLC), followed by purification through silica gel column chromatography or reverse-phase HPLC, yielding white powder with purity ≥98%. This reagent finds extensive applications in biomolecular labeling (e.g., BCN modification of antibodies/nucleic acids), in vivo imaging (targeting azide-modified tumor cells), and functionalization of drug delivery systems (modifying nanocarriers for targeted conjugation). Its copper-free click chemistry properties and high coupling efficiency (>90%) make it an important tool in chemical biology research.
所属分类： BCN类
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