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Propargyl-PEG4-bromide
- 商品名称： Propargyl-PEG4-bromide
- Product No.： BK03187
- Product Name： Propargyl-PEG4-bromide
- 中文名称： 丙炔基-四聚乙二醇-溴代
- CAS.： 1308299-09-3
- Formula： C11H19BrO4
- M.W.： 295.17
相关描述
Propargyl-PEG4-bromide (CAS 1308299-09-3) is a polyethylene glycol (PEG) derivative containing an alkyne group (-C≡CH) and a bromine atom (-Br), with the molecular formula C₁₁H₁₉BrO₄ and a molecular weight of 295.17. Its structure consists of a PEG4 chain linking the propargyl group and the bromine atom, combining hydrophilicity and reactivity. Production typically involves a two-step process: first introducing the propargyl group into the PEG chain via acetylenation, then incorporating the bromine atom through bromination, which must be carried out under anhydrous and oxygen-free conditions to avoid side reactions. This reagent is widely used in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions as a PROTAC linker or an irreversible ADC linker for targeted protein degradation and antibody-drug conjugate synthesis, holding significant value in biomedical research and drug development.
所属分类： 丙炔基链接剂
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