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Propargyl-PEG2-t-butyl ester cas:1807503-80-5
- 商品名称： Propargyl-PEG2-t-butyl ester cas:1807503-80-5
- Product No.： BK03088
- Product Name： Propargyl-PEG2-t-butyl ester
- 中文名称： 丙炔基-一聚乙二醇-丙酸叔丁酯
- Appearance： 液态
- CAS.： 1807503-80-5
- Formula： C12H20O4
- M.W.： 228.28
相关描述
Propargyl-PEG2-t-butyl ester is a PEG2 derivative containing a propargyl group and a t-butyl ester, with the molecular formula C₁₂H₂₀O₄ and a molecular weight of 228.28. Its structure consists of a propargyl group linked to the PEG2 chain via an ether bond, with the carboxyl group protected by a t-butyl ester at the terminal end, combining the click chemistry reactivity of the alkyne group with the biocompatibility of PEG.
The production process involves a two-step chemical synthesis: first, constructing the PEG2 backbone through etherification of propyne with diglycidyl ether, followed by esterification with t-butyl propanoate to form the final product.
This reagent is widely used in bioorthogonal labeling, PROTAC molecule synthesis, and drug delivery systems. Its alkyne group can efficiently couple with azides via copper-catalyzed cycloaddition (CuAAC). The t-butyl ester can be deprotected under weak acidic conditions to release the free carboxyl group, making it suitable for protein modification, fluorescent probe development, and nanomaterial functionalization.
所属分类： 丙炔基链接剂
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