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Bis-propargyl-PEG7
- 商品名称： Bis-propargyl-PEG7
- Product No.： BK02219
- Product Name： Bis-propargyl-PEG7
- 中文名称： 丙炔基-七聚乙二醇-丙炔基
- Appearance： 液态
- CAS.： 1351373-46-0
- Formula： C20H34O8
- M.W.： 402.48
相关描述
Bis-propargyl-PEG7 (CAS No. 400775-35-1) is a linear molecule with polyethylene glycol (PEG7) as its backbone, modified by propargyl groups (-C≡CH) at both ends. Its molecular formula is C₁₈H₃₀O₇, and its molecular weight is 358.43. The structure forms a flexible hydrophilic chain through the repetitive connection of ethylene glycol units, with the terminal alkynes providing reactive sites for click chemistry reactions. The production process employs precisely controlled ethylene glycol polymerization and terminal alkyne modification technologies to ensure monodispersity in molecular weight (purity ≥95%). This compound is widely used in PROTAC technology as a degrader linker, enabling the directed conjugation of target proteins with E3 ligases via participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. It is also utilized in the synthesis of cyclic nucleotide polymers, serving as tools for signal transduction research or affinity chromatography ligands.
所属分类： 丙炔基链接剂
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