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Benzyl-PEG9-THP
- 商品名称： Benzyl-PEG9-THP
- Product No.： BK03334
- Product Name： Benzyl-PEG9-THP
- 中文名称： 苄基-九聚乙二醇-四氢吡喃醚
- Appearance： 液态
- Formula： C30H52O11
- M.W.： 588.73
相关描述
Benzyl-PEG9-THP (CAS No.: 669556-53-0) is a PEG-based PROTAC linker with the molecular formula C₃₀H₅₂O₁₁ and a molecular weight of 588.73. Structurally, it consists of a benzyl group connected via nine ethylene glycol units (PEG9) to a tetrahydrofuran ether (THP) moiety. This structure combines hydrophilic and hydrophobic properties, allowing flexible adjustment of the spatial conformation of PROTAC molecules. The production process typically involves stepwise condensation reactions, achieving high-purity synthesis through precise control of the polymerization degree of ethylene glycol units and the capping reaction of THP groups. As a core component of PROTAC technology, it is widely used in the development of targeted protein degradation drugs. By linking E3 ubiquitin ligase ligands with target protein ligands, it induces ubiquitination and degradation of target proteins, demonstrating significant research value in fields such as cancer therapy.
所属分类： 苄基链接剂
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