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THP-PEG24-THP
- 商品名称： THP-PEG24-THP
- Product No.： BK03345
- Product Name： THP-PEG24-THP
- 中文名称： 四氢吡喃醚-二十四聚乙二醇-四氢吡喃醚
- Appearance： 液态
- Formula： C59H116O26
- M.W.： 1241.54
相关描述
THP-PEG24-THP is a symmetric PROTAC linker based on 24-unit polyethylene glycol (PEG24), terminated with tetrahydrofuran ether (THP) groups at both ends, forming a linear molecular structure. Its production employs high-purity monodisperse PEG raw materials, with precise chemical coupling reactions to control chain length (n=24) and the introduction of THP protecting groups to enhance stability. As a core component of PROTAC technology, this molecule connects E3 ubiquitin ligase ligands with target protein ligands, enabling selective degradation of target proteins via the ubiquitin-proteasome system. Its ultra-long flexible chain (approximately 12-15 nm) effectively reduces steric hindrance and improves drug release efficiency. It is widely applied in tumor-targeted therapy, protein function regulation, and the development of novel drug delivery systems.
所属分类： 四氢吡喃醚链接剂
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