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THP-PEG10-t butyl ester
- 商品名称： THP-PEG10-t butyl ester
- Product No.： BK03366
- Product Name： THP-PEG10-t butyl ester
- 中文名称： 四氢吡喃醚-十聚乙二醇-丙酸叔丁酯
- Appearance： 液态
- Formula： C32H62O14
- M.W.： 670.83
相关描述
THP-PEG10-t-butyl ester is a functionalized polyethylene glycol derivative, consisting of a tetrahydrofuran ether (THP) protecting group, a decylene glycol (PEG10) segment, and a t-butyl ester group in its structure. The production process involves multiple reaction steps: first, the PEG10 chain is synthesized, followed by the introduction of disulfide bonds or THP protecting groups via nucleophilic reactions, and finally, the t-butyl ester group is connected to the molecular terminus through esterification. This compound combines hydrophilicity (from the PEG chain) with chemical protection properties (from THP/t-butyl ester). It is used in bioconjugation for temporary protection of carboxyl groups or as a flexible linker arm in protein modification to optimize ligand spatial conformation and enhance degradation efficiency. Its application areas include antibody-drug conjugate (ADC) development, PROTAC technology, and nanomaterial functionalization.
所属分类： 四氢吡喃醚链接剂
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