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tert-Butyl methyl(5-oxopentyl)carba mate
- 商品名称： tert-Butyl methyl(5-oxopentyl)carba mate
- Product No.： BK03218
- Product Name： tert-Butyl methyl(5-oxopentyl)carba mate
- 中文名称： 甲基(5-氧代戊基)氨基甲酸叔丁酯
- CAS.： 1620280-47-8
- Formula： C11H21NO3
- M.W.： 215.29
相关描述
This compound (CAS number: 1620280-47-8) belongs to the PROTAC linker class, with a molecular formula of C₁₁H₂₁NO₃ and a molecular weight of 215.29. Its structure consists of an N-methyl amino group protected by a tert-butyloxycarbonyl (Boc) group connected to a 5-oxopentyl group (—CH₂CH₂CH₂COCH₃) via an amide bond, forming a linear molecular backbone. The production process typically starts with 5-oxopentanal, undergoing nucleophilic addition with Boc-protected methylamine, followed by oxidation and purification steps. Strict temperature control (e.g., reaction at 0°C) is required to avoid side reactions. As a key component of PROTAC technology, this linker connects the target protein ligand and E3 ubiquitin ligase ligand through a flexible alkyl chain, promoting the formation of a ternary complex. It is widely used in the development of tumor-targeted protein degradation drugs and chemical biology research.
所属分类： 甲酸叔丁酯链接剂
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